Overexpression of Lrp5 enhanced the anti-breast cancer effects of osteocytes in bone

Overexpression of Lrp5 enhanced the anti-breast cancer effects of osteocytes in bone

Abstract Osteocytes are the most abundant cells in bone, which is a frequent site of breast cancer metastasis. Here, we focused on Wnt signaling and evaluated tumor-osteocyte interactions. In animal experiments, mammary tumor cells were inoculated into the mammary fat pad and tibia. The role of Lrp5...

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Bibliographic Details
Main Authors: Shengzhi Liu, Di Wu, Xun Sun, Yao Fan, Rongrong Zha, Aydin Jalali, Yan Feng, Kexin Li, Tomohiko Sano, Nicole Vike, Fangjia Li, Joseph Rispoli, Akihiro Sudo, Jing Liu, Alexander Robling, Harikrishna Nakshatri, Bai-Yan Li, Hiroki Yokota
Format: Article
Language:English
Published: Nature Publishing Group 2021-07-01
Series:Bone Research
Online Access:https://doi.org/10.1038/s41413-021-00152-2

Internet

https://doi.org/10.1038/s41413-021-00152-2

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