Glutamatergic synaptic plasticity in the mesocorticolimbic system in addiction

Addictive drugs remodel the brain’s reward circuitry, the mesocorticolimbic dopamine system, by inducing widespread adaptations of glutamatergic synapses. This drug-induced synaptic plasticity is thought to contribute to both the development and the persistence of addiction. This review highlights t...

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Bibliographic Details
Main Authors: Aile evan Huijstee, Huib eMansvelder
Format: Article
Language:English
Published: Frontiers Media S.A. 2015-01-01
Series:Frontiers in Cellular Neuroscience
Subjects:
Online Access:http://journal.frontiersin.org/Journal/10.3389/fncel.2014.00466/full