Liver-Targeted Combination Therapy Basing on Glycyrrhizic Acid-Modified DSPE-PEG-PEI Nanoparticles for Co-delivery of Doxorubicin and Bcl-2 siRNA

Liver-Targeted Combination Therapy Basing on Glycyrrhizic Acid-Modified DSPE-PEG-PEI Nanoparticles for Co-delivery of Doxorubicin and Bcl-2 siRNA

Combination therapy based on nano-sized drug delivery system has been developed as a promising strategy by combining two or more anti-tumor mechanisms. Here, we prepared liver-targeted nanoparticles (GH-DPP) composed of 1,2-distearoyl-sn-glycero-3-phosphoethanolamine-polyethylene glycol-polyetherimi...

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Bibliographic Details
Main Authors: Guixiang Tian, Ruiyan Pan, Bo Zhang, Meihua Qu, Bo Lian, Hong Jiang, Zhiqin Gao, Jingliang Wu
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-01-01
Series:Frontiers in Pharmacology
Subjects:
combination therapy
nanoparticles
delivery
liver cancer
glycyrrhizic acid
Online Access:https://www.frontiersin.org/article/10.3389/fphar.2019.00004/full

Internet

https://www.frontiersin.org/article/10.3389/fphar.2019.00004/full

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