Spatial memory deficits in a mouse model of late-onset Alzheimer’s disease are caused by zinc supplementation and correlate with amyloid-beta levels

Much of the research in Alzheimer’s disease (AD) that uses mouse models focuses on the early-onset form of the disease, which accounts for less than 5% of cases. In contrast, this study used a late-onset AD model to examine the interaction between increased dietary zinc (Zn) and the apolipoprotein E...

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Bibliographic Details
Main Authors: Jane Margaret Flinn, Parviz Lorenzo Bozzelli, Paul Anthony Adlard, Angela M Railey
Format: Article
Language:English
Published: Frontiers Media S.A. 2014-10-01
Series:Frontiers in Aging Neuroscience
Subjects:
Online Access:http://journal.frontiersin.org/Journal/10.3389/fnagi.2014.00174/full