The Division of Amyloid Fibrils: Systematic Comparison of Fibril Fragmentation Stability by Linking Theory with Experiments

Summary: The division of amyloid protein fibrils is required for the propagation of the amyloid state and is an important contributor to their stability, pathogenicity, and normal function. Here, we combine kinetic nanoscale imaging experiments with analysis of a mathematical model to resolve and co...

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Bibliographic Details
Main Authors: David M. Beal, Magali Tournus, Ricardo Marchante, Tracey J. Purton, David P. Smith, Mick F. Tuite, Marie Doumic, Wei-Feng Xue
Format: Article
Language:English
Published: Elsevier 2020-09-01
Series:iScience
Subjects:
Online Access:http://www.sciencedirect.com/science/article/pii/S2589004220307045