Ufbp1, a Key Player of Ufm1 Conjugation System, Protects Against Ketosis-Induced Liver Injury via Suppressing Smad3 Activation

Ufbp1, a Key Player of Ufm1 Conjugation System, Protects Against Ketosis-Induced Liver Injury via Suppressing Smad3 Activation

The dairy cattle suffer from severe liver dysfunction during the pathogenesis of ketosis. The Ufm1 conjugation system is crucial for liver development and homeostasis. Ufm1 binding protein (Ufbp1) is a putative Ufm1 target and an integral component, but its role in ketosis-induced liver injury is un...

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Bibliographic Details
Main Authors: Fanghui Chen, Le Sheng, Chenjie Xu, Jun Li, Ilyas Ali, Honglin Li, Yafei Cai
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-07-01
Series:Frontiers in Cell and Developmental Biology
Subjects:
Ufbp1
Smad3 activation
ER stress
hepatic fibrosis
ketosis
Online Access:https://www.frontiersin.org/articles/10.3389/fcell.2021.676789/full

Internet

https://www.frontiersin.org/articles/10.3389/fcell.2021.676789/full

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