Chemical Incorporation of Chain-Terminating Nucleoside Analogs as 3′-Blocking DNA Damage and Their Removal by Human ERCC1-XPF Endonuclease

Chemical Incorporation of Chain-Terminating Nucleoside Analogs as 3′-Blocking DNA Damage and Their Removal by Human ERCC1-XPF Endonuclease

Nucleoside/nucleotide analogs that lack the 3′-hydroxy group are widely utilized for HIV therapy. These chain-terminating nucleoside analogs (CTNAs) block DNA synthesis after their incorporation into growing DNA, leading to the antiviral effects. However, they are also considered to be DNA damaging...

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Bibliographic Details
Main Authors: Junpei Yamamoto, Chiaki Takahata, Isao Kuraoka, Kouji Hirota, Shigenori Iwai
Format: Article
Language:English
Published: MDPI AG 2016-06-01
Series:Molecules
Subjects:
DNA damage
DNA repair
antiviral agents
solid-phase synthesis
nucleotide excision repair
Online Access:http://www.mdpi.com/1420-3049/21/6/766

Internet

http://www.mdpi.com/1420-3049/21/6/766

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