Excavating the functionally crucial active-site residues of the DXS protein of Bacillus subtilis by exploring its closest homologues

Excavating the functionally crucial active-site residues of the DXS protein of Bacillus subtilis by exploring its closest homologues

Abstract Background To achieve a high yield of terpenoid-based therapeutics, 1-deoxy-d-xylulose-5-phosphate (DXP) pathway has been significantly exploited for the production of downstream enzymes. The DXP synthase (DXS) enzyme, the initiator of this pathway, is pivotal for the convergence of carbon...

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Bibliographic Details
Main Authors: Ashish Runthala, Tavakala Harsha Sai, Vandana Kamjula, Suresh C. Phulara, Vikrant Singh Rajput, Karthikeyan Sangapillai
Format: Article
Language:English
Published: SpringerOpen 2020-11-01
Series:Journal of Genetic Engineering and Biotechnology
Subjects:
DXS
Motif
Phylogeny
Consurf
Coevolution
Directed evolution
Online Access:http://link.springer.com/article/10.1186/s43141-020-00087-x

Internet

http://link.springer.com/article/10.1186/s43141-020-00087-x

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