ALCOHOL AND ALDEHYDE DEHYDROGENASES CONTRIBUTE TO SEX-RELATED DIFFERENCES IN CLEARANCE OF ZOLPIDEM IN RATS

ALCOHOL AND ALDEHYDE DEHYDROGENASES CONTRIBUTE TO SEX-RELATED DIFFERENCES IN CLEARANCE OF ZOLPIDEM IN RATS

Objectives:  The recommended zolpidem starting dose was lowered in females (5mg vs 10mg) since side effects were more frequent and severe than those of males; the mechanism underlying sex differences in pharmacokinetics (PK) is unknown.  We hypothesized that such differences were caused by known sex...

Full description

Bibliographic Details
Main Authors: Cody J Peer, Jonathan D Strope, Shaunna Beedie, Ariel M Ley, Alesia Holly, Karim Calis, Ronald Farkas, Jagan Parepally, Angela Men, Emmanuel O Fadiran, Pamela Scott, Marjorie Jenkins, William H. Theodore, Tristan M Sissung
Format: Article
Language:English
Published: Frontiers Media S.A. 2016-08-01
Series:Frontiers in Pharmacology
Subjects:
Alcohol Dehydrogenase
Aldehyde Dehydrogenase
sex differences & hormone effects
zolpidem
Pharmacokinetics (PK)
Online Access:http://journal.frontiersin.org/Journal/10.3389/fphar.2016.00260/full

Internet

http://journal.frontiersin.org/Journal/10.3389/fphar.2016.00260/full

Similar Items