A toxicogenomic approach for the prediction of murine hepatocarcinogenesis using ensemble feature selection.

A toxicogenomic approach for the prediction of murine hepatocarcinogenesis using ensemble feature selection.

The current strategy for identifying the carcinogenicity of drugs involves the 2-year bioassay in male and female rats and mice. As this assay is cost-intensive and time-consuming there is a high interest in developing approaches for the screening and prioritization of drug candidates in preclinical...

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Bibliographic Details
Main Authors: Johannes Eichner, Nadine Kossler, Clemens Wrzodek, Arno Kalkuhl, Dorthe Bach Toft, Nina Ostenfeldt, Virgile Richard, Andreas Zell
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2013-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3769381?pdf=render

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http://europepmc.org/articles/PMC3769381?pdf=render

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