Krüppel-Like Factor 6 Is Required for Oxidative and Oncogene-Induced Cellular Senescence

Krüppel-Like Factor 6 Is Required for Oxidative and Oncogene-Induced Cellular Senescence

Krüppel-like factor 6 (KLF6) is a transcription factor involved in the regulation of several cellular processes. Regarding its role in tumorigenesis, KLF6 is considered a tumor suppressor. Numerous reports demonstrate its frequent genomic loss or down-regulation, implying a functional inactivation i...

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Bibliographic Details
Main Authors: Maria Eugenia Sabatino, Andrés Castellaro, Ana C. Racca, Sofía Carbajosa González, Maria Florencia Pansa, Gastón Soria, Jose Luis Bocco
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-11-01
Series:Frontiers in Cell and Developmental Biology
Subjects:
KLF6
cellular senescence
DNA damage
cell proliferation
ras oncogene
Online Access:https://www.frontiersin.org/article/10.3389/fcell.2019.00297/full

Internet

https://www.frontiersin.org/article/10.3389/fcell.2019.00297/full

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