Determinants of pH profile and acyl chain selectivity in lysosomal phospholipase A2 [S]

Determinants of pH profile and acyl chain selectivity in lysosomal phospholipase A2 [S]

Lysosomal phospholipase A2 (LPLA2) is characterized by broad substrate recognition, peak activity at acidic pH, and the transacylation of lipophilic alcohols, especially N-acetyl-sphingosine. Prior structural analysis of LPLA2 revealed the presence of an atypical acidic residue, Asp13, in the otherw...

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Bibliographic Details
Main Authors: Vania Hinkovska-Galcheva, Robert Kelly, Kelly A. Manthei, Renee Bouley, Wenmin Yuan, Anna Schwendeman, JohnJ.G. Tesmer, James A. Shayman
Format: Article
Language:English
Published: Elsevier 2018-01-01
Series:Journal of Lipid Research
Subjects:
acyltransferase
1-O-acylceramide
lysosome
phospholipase A2 group XV
crystallography
cholesterol
Online Access:http://www.sciencedirect.com/science/article/pii/S0022227520330789

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http://www.sciencedirect.com/science/article/pii/S0022227520330789

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