Identification of deleterious nsSNPs in α, μ, π and θ class of GST family and their influence on protein structure

Identification of deleterious nsSNPs in α, μ, π and θ class of GST family and their influence on protein structure

GST family genes have a critical role in xenobiotic metabolism and drug resistance. Among the GST family the GST-μ, GST-π, GST-α and GST-θ are the most abundant classes and have a major role in the carcinogen detoxification process. Nevertheless the activity of these enzymes may differ due to polymo...

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Bibliographic Details
Main Authors: P. Yadav, A. Chatterjee, A. Bhattacharjee
Format: Article
Language:English
Published: Elsevier 2014-12-01
Series:Genomics Data
Subjects:
Glutathione transferase (GST)
Non-synonymous single nucleotide polymorphism (nsSNP)
Mutant modeling
Drug resistance
Xenobiotics
Online Access:http://www.sciencedirect.com/science/article/pii/S2213596014000130

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http://www.sciencedirect.com/science/article/pii/S2213596014000130

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