Hydrophobic Interactions Drive Binding between Vascular Endothelial Growth Factor-A (VEGFA) and Polyphenolic Inhibitors

Hydrophobic Interactions Drive Binding between Vascular Endothelial Growth Factor-A (VEGFA) and Polyphenolic Inhibitors

Some polyphenols have been shown to inhibit, at physiological levels, the VEGF-induced VEGF receptor-2 signaling that causes angiogenesis, allegedly by direct interaction with VEGF and reducing the binding to its receptor VEGFR2. Surface plasmon resonance was used to measure the parameters of bindin...

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Bibliographic Details
Main Authors: Natalia Perez-Moral, Paul W. Needs, Christina W.A. Moyle, Paul A. Kroon
Format: Article
Language:English
Published: MDPI AG 2019-07-01
Series:Molecules
Subjects:
flavonoids
epigallocatechin gallate
tyrosine receptor kinases
angiogenesis
VEGF
protein
polyphenol
surface plasmon resonance (SPR)
circular dichroism (CD)
Online Access:https://www.mdpi.com/1420-3049/24/15/2785

Internet

https://www.mdpi.com/1420-3049/24/15/2785

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