Protective effects of Lactobacillus acidophilus NX2-6 against oleic acid-induced steatosis, mitochondrial dysfunction, endoplasmic reticulum stress and inflammatory responses

Protective effects of Lactobacillus acidophilus NX2-6 against oleic acid-induced steatosis, mitochondrial dysfunction, endoplasmic reticulum stress and inflammatory responses

The cell-free extract (CFE) of Lactobacillus acidophilus NX2-6 was used to treat oleic acid (OA)-exposed HepG2 cells. Biochemical analysis showed that CFE could reduce high levels of triglyceride, LDL-c, LDH, and MDA caused by OA treatment. RT-PCR and western blot analysis revealed that CFE distinct...

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Bibliographic Details
Main Authors: Chao Tang, Fanqiang Meng, Xinyi Pang, Meirong Chen, Libang Zhou, Zhaoxin Lu, Yingjian Lu
Format: Article
Language:English
Published: Elsevier 2020-11-01
Series:Journal of Functional Foods
Subjects:
Lactobacillus acidophilus
Cell-free extract
Mitochondrial dysfunction
Endoplasmic reticulum stress
Inflammation
Online Access:http://www.sciencedirect.com/science/article/pii/S1756464620304308

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