<i>IKBKB</i> siRNA-Encapsulated Poly (Lactic-<i>co</i>-Glycolic Acid) Nanoparticles Diminish Neuropathic Pain by Inhibiting Microglial Activation

<i>IKBKB</i> siRNA-Encapsulated Poly (Lactic-<i>co</i>-Glycolic Acid) Nanoparticles Diminish Neuropathic Pain by Inhibiting Microglial Activation

Activation of nuclear factor-kappa B (NF-κB) in microglia plays a decisive role in the progress of neuropathic pain, and the inhibitor of kappa B (IκB) is a protein that blocks the activation of NF-κB and is degraded by the inhibitor of NF-κB kinase subunit beta (IKBKB). The role of <i>IKBKB&l...

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Bibliographic Details
Main Authors: Seounghun Lee, Hyo-Jung Shin, Chan Noh, Song-I Kim, Young-Kwon Ko, Sun-Yeul Lee, Chaeseong Lim, Boohwi Hong, Sin-Young Yang, Dong-Woon Kim, Won-Hyung Lee, Yoon-Hee Kim
Format: Article
Language:English
Published: MDPI AG 2021-05-01
Series:International Journal of Molecular Sciences
Subjects:
neuropathic pain
microglia
<i>IKBKB</i>
siRNA
poly (lactic-<i>co</i>-glycolic acid) nanoparticle
Online Access:https://www.mdpi.com/1422-0067/22/11/5657

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https://www.mdpi.com/1422-0067/22/11/5657

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