Hepatitis C virus RNA replication depends on specific cis- and trans-acting activities of viral nonstructural proteins.

Hepatitis C virus RNA replication depends on specific cis- and trans-acting activities of viral nonstructural proteins.

Many positive-strand RNA viruses encode genes that can function in trans, whereas other genes are required in cis for genome replication. The mechanisms underlying trans- and cis-preferences are not fully understood. Here, we evaluate this concept for hepatitis C virus (HCV), an important cause of c...

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Bibliographic Details
Main Authors: Teymur Kazakov, Feng Yang, Harish N Ramanathan, Andrew Kohlway, Michael S Diamond, Brett D Lindenbach
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2015-04-01
Series:PLoS Pathogens
Online Access:http://europepmc.org/articles/PMC4395149?pdf=render

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http://europepmc.org/articles/PMC4395149?pdf=render

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