The Fanconi Anemia Pathway Protects Genome Integrity from R-loops.

The Fanconi Anemia Pathway Protects Genome Integrity from R-loops.

Co-transcriptional RNA-DNA hybrids (R loops) cause genome instability. To prevent harmful R loop accumulation, cells have evolved specific eukaryotic factors, one being the BRCA2 double-strand break repair protein. As BRCA2 also protects stalled replication forks and is the FANCD1 member of the Fanc...

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Bibliographic Details
Main Authors: María L García-Rubio, Carmen Pérez-Calero, Sonia I Barroso, Emanuela Tumini, Emilia Herrera-Moyano, Iván V Rosado, Andrés Aguilera
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2015-11-01
Series:PLoS Genetics
Online Access:http://europepmc.org/articles/PMC4652862?pdf=render

Internet

http://europepmc.org/articles/PMC4652862?pdf=render

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