Fundamentally different roles of neuronal TNF receptors in CNS pathology: TNFR1 and IKKβ promote microglial responses and tissue injury in demyelination while TNFR2 protects against excitotoxicity in mice

Fundamentally different roles of neuronal TNF receptors in CNS pathology: TNFR1 and IKKβ promote microglial responses and tissue injury in demyelination while TNFR2 protects against excitotoxicity in mice

Abstract Background During inflammatory demyelination, TNF receptor 1 (TNFR1) mediates detrimental proinflammatory effects of soluble TNF (solTNF), whereas TNFR2 mediates beneficial effects of transmembrane TNF (tmTNF) through oligodendroglia, microglia, and possibly other cell types. This model sup...

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Bibliographic Details
Main Authors: Irini Papazian, Eleni Tsoukala, Athena Boutou, Maria Karamita, Konstantinos Kambas, Lida Iliopoulou, Roman Fischer, Roland E. Kontermann, Maria C. Denis, George Kollias, Hans Lassmann, Lesley Probert
Format: Article
Language:English
Published: BMC 2021-09-01
Series:Journal of Neuroinflammation
Subjects:
Neuroinflammation
Immunotherapy
Multiple sclerosis
NF-κB
Autophagy
Neuroprotection
Online Access:https://doi.org/10.1186/s12974-021-02200-4

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