Pharmacoperone identification for therapeutic rescue of misfolded mutant proteins
G protein-coupled receptors (GPCRs), which includes the gonadotropin releasing hormone (GnRH) receptor (GnRHR), comprises the largest family of validated drug targets—more than half of all approved drugs derive their benefits by selective targeting of GPCRs. Most drugs in this class are either agoni...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
| Published: |
Frontiers Media S.A.
2011-03-01
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| Series: | Frontiers in Endocrinology |
| Subjects: | |
| Online Access: | http://journal.frontiersin.org/Journal/10.3389/fendo.2011.00006/full |