Disruption of nucleocytoplasmic trafficking of cyclin D1 and topoisomerase II by sanguinarine

<p>Abstract</p> <p>Background</p> <p>The quaternary isoquinoline alkaloid sanguinarine is receiving increasing attention as a potential chemotherapeutic agent in the treatment of cancer. Previous studies have shown that this DNA-binding phytochemical can arrest a number...

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Bibliographic Details
Main Authors: Perkins Edward, Lamont Genelle, Holy Jon
Format: Article
Language:English
Published: BMC 2006-03-01
Series:BMC Cell Biology
Online Access:http://www.biomedcentral.com/1471-2121/7/13