Pharmacological Evaluation of 3-Carbomethoxy Fentanyl in Mice

Pharmacological Evaluation of 3-Carbomethoxy Fentanyl in Mice

In many animal species, as well as in humans, high doses of fentanyl (F) produce marked neurotoxic effects, such as muscular rigidity and respiratory depression. The antinociception (hot-plate test), impairment of motor coordination (rotarod test) and acute toxicity of intraperitoneal newly synthesi...

Full description

Bibliographic Details
Main Authors: Zeljko Mikovic, Marko Kadija, Cedomir Vucetic, Katarina Savic Vujovic, Ljiljana Dosen-Micovic, Milovan Ivanovic, Sonja Vuckovic, Milica Prostran
Format: Article
Language:English
Published: MDPI AG 2011-01-01
Series:Pharmaceuticals
Subjects:
fentanyl
3-carbomethoxy fentanyl
hot plate
rotarod
acute toxicity
mice
Online Access:http://www.mdpi.com/1424-8247/4/2/233/

Internet

http://www.mdpi.com/1424-8247/4/2/233/

Similar Items