Targeting of neutral cholesterol ester hydrolase to the endoplasmic reticulum via its N-terminal sequence[S]

Targeting of neutral cholesterol ester hydrolase to the endoplasmic reticulum via its N-terminal sequence[S]

Neutral cholesterol ester hydrolase (NCEH) accounts for a large part of the nCEH activity in macrophage foam cells, a hallmark of atherosclerosis, but its subcellular localization and structure-function relationship are unknown. Here, we determined subcellular localization, glycosylation, and nCEH a...

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Bibliographic Details
Main Authors: Masaki Igarashi, Jun-ichi Osuga, Masashi Isshiki, Motohiro Sekiya, Hiroaki Okazaki, Satoru Takase, Mikio Takanashi, Keisuke Ohta, Masayoshi Kumagai, Makiko Nishi, Toshiro Fujita, Ryozo Nagai, Takashi Kadowaki, Shun Ishibashi
Format: Article
Language:English
Published: Elsevier 2010-02-01
Series:Journal of Lipid Research
Subjects:
macrophage
atherosclerosis
lipid droplets
foam cells
glycosylation
cholesterol efflux
Online Access:http://www.sciencedirect.com/science/article/pii/S0022227520305320

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http://www.sciencedirect.com/science/article/pii/S0022227520305320

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