Ethyl Acetate Extract of Selaginella doederleinii Hieron Induces Cell Autophagic Death and Apoptosis in Colorectal Cancer via PI3K-Akt-mTOR and AMPKα-Signaling Pathways

Ethyl Acetate Extract of Selaginella doederleinii Hieron Induces Cell Autophagic Death and Apoptosis in Colorectal Cancer via PI3K-Akt-mTOR and AMPKα-Signaling Pathways

Colorectal cancer is one type of cancer with high incidence rate and high mortality worldwide. Thus, developing new chemotherapeutic drugs is important. The Selaginella doederleinii Hieron ethyl acetate (SDEA) extract showed good anti-colon cancer effect in vitro and in vivo, but its mechanism is un...

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Bibliographic Details
Main Authors: Shaoguang Li, Xuewen Wang, Gang Wang, Peiying Shi, Shilan Lin, Dafen Xu, Bing Chen, Ailin Liu, Liying Huang, Xinhua Lin, Hong Yao
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-10-01
Series:Frontiers in Pharmacology
Subjects:
colorectal carcinoma
autophagy
apoptosis
Selaginella doederleinii Hieron ethyl acetate
antitumor mechanism
Online Access:https://www.frontiersin.org/article/10.3389/fphar.2020.565090/full

Internet

https://www.frontiersin.org/article/10.3389/fphar.2020.565090/full

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