Activation of p53 with Ilimaquinone and Ethylsmenoquinone, Marine Sponge Metabolites, Induces Apoptosis and Autophagy in Colon Cancer Cells

Activation of p53 with Ilimaquinone and Ethylsmenoquinone, Marine Sponge Metabolites, Induces Apoptosis and Autophagy in Colon Cancer Cells

The tumor suppressor, p53, plays an essential role in the cellular response to stress through regulating the expression of genes involved in cell cycle arrest, apoptosis and autophagy. Here, we used a cell-based reporter system for the detection of p53 response transcription to identify the marine s...

Full description

Bibliographic Details
Main Authors: Hyun-Young Lee, Kyu Jin Chung, In Hyun Hwang, Jungsuk Gwak, Seoyoung Park, Bong Gun Ju, Eunju Yun, Dong-Eun Kim, Young-Hwa Chung, MinKyun Na, Gyu-Yong Song, Sangtaek Oh
Format: Article
Language:English
Published: MDPI AG 2015-01-01
Series:Marine Drugs
Subjects:
ilimaquinone
ethylsmenoquinone
p53
colon cancer
apoptosis
autophagy
Online Access:http://www.mdpi.com/1660-3397/13/1/543

Internet

http://www.mdpi.com/1660-3397/13/1/543

Similar Items