The Role of the COP9 Signalosome and Neddylation in DNA Damage Signaling and Repair

The maintenance of genomic integrity is an important process in organisms as failure to sense and repair damaged DNA can result in a variety of diseases. Eukaryotic cells have developed complex DNA repair response (DDR) mechanisms to accurately sense and repair damaged DNA. Post-translational modifi...

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Bibliographic Details
Main Authors: Dudley Chung, Graham Dellaire
Format: Article
Language:English
Published: MDPI AG 2015-09-01
Series:Biomolecules
Subjects:
Online Access:http://www.mdpi.com/2218-273X/5/4/2388