Q63, a novel DENV2 RdRp non-nucleoside inhibitor, inhibited DENV2 replication and infection

Q63, a novel DENV2 RdRp non-nucleoside inhibitor, inhibited DENV2 replication and infection

Dengue virus (DENV) annually infects 400 million people worldwide. Unfortunately, there is lack of widely protective vaccine or drugs against DENV. The viral RNA-dependent RNA polymerase (RdRp) of NS5 protein is highly conserved among different DENV subtypes, thus presenting itself as an attractive...

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Bibliographic Details
Main Authors: Xingang Yao, Songxin Guo, Wenyu Wu, Jinan Wang, Shengen Wu, Shijun He, Yihong Wan, Kutty Selva Nandakumar, Xiaoguang Chen, Ning Sun, Qiuhua Zhu, Shuwen Liu
Format: Article
Language:English
Published: Elsevier 2018-12-01
Series:Journal of Pharmacological Sciences
Online Access:http://www.sciencedirect.com/science/article/pii/S1347861318301142

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http://www.sciencedirect.com/science/article/pii/S1347861318301142

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