Yeast-Based Genetic Interaction Analysis of Human Kinome

Yeast-Based Genetic Interaction Analysis of Human Kinome

Kinases are critical intracellular signaling proteins. To better understand kinase-mediated signal transduction, a large-scale human–yeast genetic interaction screen was performed. Among 597 human kinase genes tested, 28 displayed strong toxicity in yeast when overexpressed. <i>En masse</i&...

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Bibliographic Details
Main Authors: Jae-Hong Kim, Yeojin Seo, Myungjin Jo, Hyejin Jeon, Won-Ha Lee, Nozomu Yachie, Quan Zhong, Marc Vidal, Frederick P. Roth, Kyoungho Suk
Format: Article
Language:English
Published: MDPI AG 2020-05-01
Series:Cells
Subjects:
yeast
kinase
genetic interaction
network
bar-seq
Online Access:https://www.mdpi.com/2073-4409/9/5/1156

Internet

https://www.mdpi.com/2073-4409/9/5/1156

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