Multi-omic analysis elucidates the genetic basis of hydrocephalus

Summary: We conducted PrediXcan analysis of hydrocephalus risk in ten neurological tissues and whole blood. Decreased expression of MAEL in the brain was significantly associated (Bonferroni-adjusted p < 0.05) with hydrocephalus. PrediXcan analysis of brain imaging and genomics data in the indepe...

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Bibliographic Details
Main Authors: Andrew T. Hale, Lisa Bastarache, Diego M. Morales, John C. Wellons, III, David D. Limbrick, Jr., Eric R. Gamazon
Format: Article
Language:English
Published: Elsevier 2021-05-01
Series:Cell Reports
Subjects:
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124721004186