Interferon regulatory factor-8 is important for histone deacetylase inhibitor-mediated antitumor activity.

Interferon regulatory factor-8 is important for histone deacetylase inhibitor-mediated antitumor activity.

The notion that epigenetic alterations in neoplasia are reversible has provided the rationale to identify epigenetic modifiers for their ability to induce or enhance tumor cell death. Histone deacetylase inhibitors (HDACi) represent one such class of anti-neoplastic agents. Despite great interest fo...

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Bibliographic Details
Main Authors: Debarati Banik, A Nazmul H Khan, Even Walseng, Brahm H Segal, Scott I Abrams
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2012-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3446900?pdf=render

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http://europepmc.org/articles/PMC3446900?pdf=render

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