AMPA receptors are the major mediators of excitotoxic death in mature oligodendrocytes

AMPA receptors are the major mediators of excitotoxic death in mature oligodendrocytes

Myelination of axons is important for central nervous system function, but oligodendrocytes, which constitute CNS myelin, are vulnerable to excitotoxic injury and death. Although mature oligodendrocytes express functional α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic (AMPA) and kainate-type glutam...

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Bibliographic Details
Main Authors: Elizabeth A Leuchtmann, Andrea E Ratner, Rattanavijit Vijitruth, Yun Qu, John W McDonald
Format: Article
Language:English
Published: Elsevier 2003-12-01
Series:Neurobiology of Disease
Subjects:
AMPA
Demyelination
Excitotoxicity
Glutamate
Kainate
Myelin
Online Access:http://www.sciencedirect.com/science/article/pii/S0969996103001657

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http://www.sciencedirect.com/science/article/pii/S0969996103001657

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