Piezo1 channel activation in response to mechanobiological acoustic radiation force in osteoblastic cells

Abstract Mechanobiological stimuli, such as low-intensity pulsed ultrasound (LIPUS), have been shown to promote bone regeneration and fresh fracture repair, but the fundamental biophysical mechanisms involved remain elusive. Here, we propose that a mechanosensitive ion channel of Piezo1 plays a pivo...

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Bibliographic Details
Main Authors: Guangdao Zhang, Xiaofei Li, Lin Wu, Yi-Xian Qin
Format: Article
Language:English
Published: Nature Publishing Group 2021-03-01
Series:Bone Research
Online Access:https://doi.org/10.1038/s41413-020-00124-y