Inhibition of Polo-like kinase 4 induces mitotic defects and DNA damage in diffuse large B-cell lymphoma

Inhibition of Polo-like kinase 4 induces mitotic defects and DNA damage in diffuse large B-cell lymphoma

Abstract Polo-like kinase 4 (PLK4), a key regulator of centriole biogenesis, has recently been shown to play key roles in tumorigenesis. Blocking PLK4 expression by interference or targeted drugs exhibits attractive potential in improving the efficacy of chemotherapy. Nevertheless, the role of PLK4...

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Bibliographic Details
Main Authors: Yi Zhao, Juan Yang, Jiarui Liu, Yiqing Cai, Yang Han, Shunfeng Hu, Shuai Ren, Xiangxiang Zhou, Xin Wang
Format: Article
Language:English
Published: Nature Publishing Group 2021-06-01
Series:Cell Death and Disease
Online Access:https://doi.org/10.1038/s41419-021-03919-x

Internet

https://doi.org/10.1038/s41419-021-03919-x

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