Development and Evaluation of Poorly Water-Soluble Celecoxib as Solid Dispersions Containing Nonionic Surfactants Using Fluidized-Bed Granulation

Development and Evaluation of Poorly Water-Soluble Celecoxib as Solid Dispersions Containing Nonionic Surfactants Using Fluidized-Bed Granulation

The purpose of this study is to develop a solid dispersion system with improved dissolution, absorption, and patient compliance of poorly water-soluble celecoxib (CXB). Instead of sodium lauryl sulfate (SLS), an anionic surfactant used in the marketed product (Celebrex<sup>&#174;</sup&g...

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Bibliographic Details
Main Authors: Hyeok Jin Kwon, Eun-Ji Heo, Young-Hwan Kim, Sarah Kim, Young-Ha Hwang, Ji-Mi Byun, Se Hyeop Cheon, Sang Yeob Park, Dong Yun Kim, Kwan Hyung Cho, Han-Joo Maeng, Dong-Jin Jang
Format: Article
Language:English
Published: MDPI AG 2019-03-01
Series:Pharmaceutics
Subjects:
celecoxib
solid dispersion
nonionic surfactants
Cremophor RH40
fluid-bed granulation
tableting
pharmacokinetics
Online Access:https://www.mdpi.com/1999-4923/11/3/136

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https://www.mdpi.com/1999-4923/11/3/136

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