Heteromerization of Endogenous Mu and Delta Opioid Receptors Induces Ligand-Selective Co-Targeting to Lysosomes

Heteromerization of Endogenous Mu and Delta Opioid Receptors Induces Ligand-Selective Co-Targeting to Lysosomes

Increasing evidence indicates that native mu and delta opioid receptors can associate to form heteromers in discrete brain neuronal circuits. However, little is known about their signaling and trafficking. Using double-fluorescent knock-in mice, we investigated the impact of neuronal co-expression o...

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Bibliographic Details
Main Authors: Lyes Derouiche, Florian Pierre, Stéphane Doridot, Stéphane Ory, Dominique Massotte
Format: Article
Language:English
Published: MDPI AG 2020-09-01
Series:Molecules
Subjects:
mu opioid receptor
delta opioid receptor
heteromer
internalization
primary hippocampal culture
lysosomes
Online Access:https://www.mdpi.com/1420-3049/25/19/4493

Internet

https://www.mdpi.com/1420-3049/25/19/4493

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