Cholesterol-secreting and statin-responsive hepatocytes from human ES and iPS cells to model hepatic involvement in cardiovascular health.

Cholesterol-secreting and statin-responsive hepatocytes from human ES and iPS cells to model hepatic involvement in cardiovascular health.

Hepatocytes play a central and crucial role in cholesterol and lipid homeostasis, and their proper function is of key importance for cardiovascular health. In particular, hepatocytes (especially periportal hepatocytes) endogenously synthesize large amounts of cholesterol and secrete it into circulat...

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Bibliographic Details
Main Authors: Winfried H Krueger, Borko Tanasijevic, Vanessa Barber, Anthony Flamier, Xinsheng Gu, Jose Manautou, Theodore P Rasmussen
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2013-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3708950?pdf=render

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http://europepmc.org/articles/PMC3708950?pdf=render

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