Novel COX-2 products of n-3 polyunsaturated fatty acid-ethanolamine-conjugates identified in RAW264.7 macrophages

Novel COX-2 products of n-3 polyunsaturated fatty acid-ethanolamine-conjugates identified in RAW264.7 macrophages

Cyclooxygenase 2 (COX-2) plays a key role in the regulation of inflammation by catalyzing the oxygenation of PUFAs to prostaglandins (PGs) and hydroperoxides. Next to this, COX-2 can metabolize neutral lipids, including endocannabinoid-like esters and amides. We developed an LC-HRMS-based human reco...

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Bibliographic Details
Main Authors: Ian de Bus, Han Zuilhof, Renger Witkamp, Michiel Balvers, Bauke Albada
Format: Article
Language:English
Published: Elsevier 2019-11-01
Series:Journal of Lipid Research
Subjects:
cyclooxygenase
fatty acid amides
fatty acid oxidation
high-performance liquid chromatography
inflammation
mass spectrometry
Online Access:http://www.sciencedirect.com/science/article/pii/S0022227520322823

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http://www.sciencedirect.com/science/article/pii/S0022227520322823

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