Effect of Bile Duct Ligation-induced Liver Dysfunction on Methamphetamine Pharmacokinetics and Locomotor Activity in Rats

Purpose: Methamphetamine (METH) abuse is associated with hepatic dysfunction related comorbidities such as HIV, hepatitis C, and polysubstance abuse with acetaminophen-containing opioid formulations. We aimed to develop a bile duct ligation (BDL)-induced hepatic dysfunction model for studying both...

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Bibliographic Details
Main Authors: Michael D Hambuchen, Michael D Berquist, Christy M Simecka, Mitchell R McGill, Melinda G Gunnell, Howard P Hendrickson, S Michael Owens
Format: Article
Language:English
Published: Canadian Society for Pharmaceutical Sciences 2019-07-01
Series:Journal of Pharmacy & Pharmaceutical Sciences
Online Access:https://journals.library.ualberta.ca/jpps/index.php/JPPS/article/view/30471