The Plasma Membrane Ca<sup>2+</sup> Pump PMCA4b Regulates Melanoma Cell Migration Through Remodeling of the Actin Cytoskeleton

The Plasma Membrane Ca<sup>2+</sup> Pump PMCA4b Regulates Melanoma Cell Migration Through Remodeling of the Actin Cytoskeleton

We demonstrated that the plasma membrane Ca<sup>2+</sup> ATPase PMCA4b inhibits migration and metastatic activity of BRAF mutant melanoma cells. Actin dynamics are essential for cells to move, invade and metastasize, therefore, we hypothesized that PMCA4b affected cell migration through...

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Bibliographic Details
Main Authors: Randa Naffa, Rita Padányi, Attila Ignácz, Zoltán Hegyi, Bálint Jezsó, Sarolta Tóth, Karolina Varga, László Homolya, Luca Hegedűs, Katalin Schlett, Agnes Enyedi
Format: Article
Language:English
Published: MDPI AG 2021-03-01
Series:Cancers
Subjects:
plasma membrane Ca<sup>2+</sup>ATPase 4b
BRAF mutant melanoma
actin cytoskeleton
cofilin
cell motility
metastasis
Online Access:https://www.mdpi.com/2072-6694/13/6/1354

Internet

https://www.mdpi.com/2072-6694/13/6/1354

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