Secreted human amyloid precursor protein binds semaphorin 3a and prevents semaphorin-induced growth cone collapse.

Secreted human amyloid precursor protein binds semaphorin 3a and prevents semaphorin-induced growth cone collapse.

The amyloid precursor protein (APP) is well known for giving rise to the amyloid-β peptide and for its role in Alzheimer's disease. Much less is known, however, on the physiological roles of APP in the development and plasticity of the central nervous system. We have used phage display of a pep...

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Bibliographic Details
Main Authors: Margaret H Magdesian, Matthias Gralle, Luiz H Guerreiro, Paulo José I Beltrão, Milena M V F Carvalho, Luís Eduardo da S Santos, Fernando G de Mello, Ricardo A M Reis, Sérgio T Ferreira
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2011-01-01
Series:PLoS ONE
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/21829538/pdf/?tool=EBI

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https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/21829538/pdf/?tool=EBI

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