Oxidation inhibits autophagy protein deconjugation from phagosomes to sustain MHC class II restricted antigen presentation

Oxidation inhibits autophagy protein deconjugation from phagosomes to sustain MHC class II restricted antigen presentation

LC3-associated phagocytosis (LAP) is a non-canonical use of the autophagy machinery that can contribute to immune responses. Here, the authors describe the mechanism by which ROS production regulates LAPosome stabilization sustaining MHC II dependent antigen presentation.

Bibliographic Details
Main Authors: Laure-Anne Ligeon, Maria Pena-Francesch, Liliana Danusia Vanoaica, Nicolás Gonzalo Núñez, Deepti Talwar, Tobias P. Dick, Christian Münz
Format: Article
Language:English
Published: Nature Publishing Group 2021-03-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-021-21829-6

Internet

https://doi.org/10.1038/s41467-021-21829-6

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