How B-Cell Receptor Repertoire Sequencing Can Be Enriched with Structural Antibody Data

How B-Cell Receptor Repertoire Sequencing Can Be Enriched with Structural Antibody Data

Next-generation sequencing of immunoglobulin gene repertoires (Ig-seq) allows the investigation of large-scale antibody dynamics at a sequence level. However, structural information, a crucial descriptor of antibody binding capability, is not collected in Ig-seq protocols. Developing systematic rela...

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Bibliographic Details
Main Authors: Aleksandr Kovaltsuk, Konrad Krawczyk, Jacob D. Galson, Dominic F. Kelly, Charlotte M. Deane, Johannes Trück
Format: Article
Language:English
Published: Frontiers Media S.A. 2017-12-01
Series:Frontiers in Immunology
Subjects:
Ig-seq
antibody modeling
B cell
Antibodies
Developability
computational modeling
Online Access:http://journal.frontiersin.org/article/10.3389/fimmu.2017.01753/full

Internet

http://journal.frontiersin.org/article/10.3389/fimmu.2017.01753/full

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