TCR and Inflammatory Signals Tune Human MAIT Cells to Exert Specific Tissue Repair and Effector Functions

TCR and Inflammatory Signals Tune Human MAIT Cells to Exert Specific Tissue Repair and Effector Functions

Summary: MAIT cells are an unconventional T cell population that can be activated through both TCR-dependent and TCR-independent mechanisms. Here, we examined the impact of combinations of TCR-dependent and TCR-independent signals in human CD8+ MAIT cells. TCR-independent activation of these MAIT ce...

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Bibliographic Details
Main Authors: Tianqi Leng, Hossain Delowar Akther, Carl-Philipp Hackstein, Kate Powell, Thomas King, Matthias Friedrich, Zoe Christoforidou, Sarah McCuaig, Mastura Neyazi, Carolina V. Arancibia-Cárcamo, Joachim Hagel, Fiona Powrie, Raphael Sanches Peres, Val Millar, Daniel Ebner, Rajesh Lamichhane, James Ussher, Timothy S.C. Hinks, Emanuele Marchi, Chris Willberg, Paul Klenerman
Format: Article
Language:English
Published: Elsevier 2019-09-01
Series:Cell Reports
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124719310988

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http://www.sciencedirect.com/science/article/pii/S2211124719310988

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