Prostaglandin E2 Impairs P2Y2/P2Y4 Receptor Signaling in Cerebellar Astrocytes via EP3 Receptors

Prostaglandin E2 Impairs P2Y2/P2Y4 Receptor Signaling in Cerebellar Astrocytes via EP3 Receptors

Prostaglandin E2 (PGE2) is an important bioactive lipid that accumulates after tissue damage or inflammation due to the rapid expression of cyclooxygenase 2. PGE2 activates specific G-protein coupled EP receptors and it mediates pro- or anti-inflammatory actions depending on the cell-context. Nucleo...

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Bibliographic Details
Main Authors: Lucía Paniagua-Herranz, Juan C. Gil-Redondo, Ma José Queipo, Silvia González-Ramos, Lisardo Boscá, Raquel Pérez-Sen, Ma Teresa Miras-Portugal, Esmerilda G. Delicado
Format: Article
Language:English
Published: Frontiers Media S.A. 2017-12-01
Series:Frontiers in Pharmacology
Subjects:
astrocytes
calcium
EP receptors
nucleotide receptor
P2Y receptors
PGE2
Online Access:http://journal.frontiersin.org/article/10.3389/fphar.2017.00937/full

Internet

http://journal.frontiersin.org/article/10.3389/fphar.2017.00937/full

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