Activated cMET and IGF1R-driven PI3K signaling predicts poor survival in colorectal cancers independent of KRAS mutational status.

Activated cMET and IGF1R-driven PI3K signaling predicts poor survival in colorectal cancers independent of KRAS mutational status.

Oncogenic mutational analysis provides predictive guidance for therapeutics such as anti-EGFR antibodies, but it is successful only for a subset of colorectal cancer (CRC) patients.A comprehensive molecular profiling of 120 CRC patients, including 116 primary, 15 liver metastasis, and 1 peritoneal s...

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Bibliographic Details
Main Authors: Jeeyun Lee, Anjali Jain, Phillip Kim, Tani Lee, Anne Kuller, Fred Princen, In-GuDo, Suk Hyeong Kim, Joon Oh Park, Young Suk Park, Sharat Singh, Hee Cheol Kim
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2014-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC4121133?pdf=render

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http://europepmc.org/articles/PMC4121133?pdf=render

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