Architectural Principles for Characterizing the Performance of Antithetic Integral Feedback Networks

Summary: As we begin to design increasingly complex synthetic biomolecular systems, it is essential to develop rational design methodologies that yield predictable circuit performance. Here we apply mathematical tools from the theory of control and dynamical systems to yield practical insights into...

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Bibliographic Details
Main Authors: Noah Olsman, Fangzhou Xiao, John C. Doyle
Format: Article
Language:English
Published: Elsevier 2019-04-01
Series:iScience
Online Access:http://www.sciencedirect.com/science/article/pii/S2589004219301014