In-vivo Imaging of Mitochondrial Depolarization of Myocardium With Positron Emission Tomography and a Proton Gradient Uncoupler

In-vivo Imaging of Mitochondrial Depolarization of Myocardium With Positron Emission Tomography and a Proton Gradient Uncoupler

BackgroundWe recently reported a method using positron emission tomography (PET) and the tracer 18F-labeled tetraphenylphosphonium (18F-TPP+) for mapping the tissue (i.e., cellular plus mitochondrial) membrane potential (ΔΨT) in the myocardium. The purpose of this work is to provide additional exper...

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Bibliographic Details
Main Authors: Nathaniel M. Alpert, Matthieu Pelletier-Galarneau, Sally Ji Who Kim, Yoann Petibon, Tao Sun, Karla M. Ramos-Torres, Marc D. Normandin, Georges El Fakhri
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-05-01
Series:Frontiers in Physiology
Subjects:
mitochondrial membrane potential
tissue membrane potential
tetraphenylphosphonium
positron emission tomography
BAM15
Online Access:https://www.frontiersin.org/article/10.3389/fphys.2020.00491/full

Internet

https://www.frontiersin.org/article/10.3389/fphys.2020.00491/full

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