Safety and Tolerability Study of an Intravenously Administered Small Interfering Ribonucleic Acid (siRNA) Post On-Pump Cardiothoracic Surgery in Patients at Risk of Acute Kidney Injury

Safety and Tolerability Study of an Intravenously Administered Small Interfering Ribonucleic Acid (siRNA) Post On-Pump Cardiothoracic Surgery in Patients at Risk of Acute Kidney Injury

Patients undergoing on-pump cardiac surgery are at an increased risk of acute kidney injury. QPI-1002, a small interfering ribonucleic acid, is under clinical development for the prevention of acute kidney injury. The safety, tolerability, and pharmacokinetics of QPI-1002 was evaluated in this first...

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Bibliographic Details
Main Authors: Segav Demirjian, Gorav Ailawadi, Martin Polinsky, Dani Bitran, Shuli Silberman, Stanton Keith Shernan, Michel Burnier, Marta Hamilton, Elizabeth Squiers, Shai Erlich, Daniel Rothenstein, Samina Khan, Lakhmir S. Chawla
Format: Article
Language:English
Published: Elsevier 2017-09-01
Series:Kidney International Reports
Subjects:
acute kidney injury
cardiopulmonary bypass
clinical trial
oligonucleotide
pharmacokinetics
siRNA
Online Access:http://www.sciencedirect.com/science/article/pii/S2468024917300992

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http://www.sciencedirect.com/science/article/pii/S2468024917300992

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