Minimax and admissible adaptive two-stage designs in phase II clinical trials

Minimax and admissible adaptive two-stage designs in phase II clinical trials

Abstract Background Simon’s two-stage design is the most widely implemented among multi-stage designs in phase II clinical trials to assess the activity of a new treatment in a single-arm study. In this two-stage design, the sample size from the second stage is fixed regardless of the number of resp...

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Bibliographic Details
Main Authors: Guogen Shan, Hua Zhang, Tao Jiang
Format: Article
Language:English
Published: BMC 2016-08-01
Series:BMC Medical Research Methodology
Subjects:
Adaptive design
Admissible design
Efficacy
Futility
Minimax design
Simon’s design
Online Access:http://link.springer.com/article/10.1186/s12874-016-0194-3

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http://link.springer.com/article/10.1186/s12874-016-0194-3

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