Crosstalk between codon optimality and cis-regulatory elements dictates mRNA stability

Crosstalk between codon optimality and cis-regulatory elements dictates mRNA stability

Abstract Background The regulation of messenger RNA (mRNA) stability has a profound impact on gene expression dynamics during embryogenesis. For example, in animals, maternally deposited mRNAs are degraded after fertilization to enable new developmental trajectories. Regulatory sequences in 3′ untra...

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Bibliographic Details
Main Authors: Santiago Gerardo Medina-Muñoz, Gopal Kushawah, Luciana Andrea Castellano, Michay Diez, Michelle Lynn DeVore, María José Blanco Salazar, Ariel Alejandro Bazzini
Format: Article
Language:English
Published: BMC 2021-01-01
Series:Genome Biology
Subjects:
Codon optimality
MicroRNA
miR-430
m6A
Zebrafish
Xenopus
Online Access:https://doi.org/10.1186/s13059-020-02251-5

Internet

https://doi.org/10.1186/s13059-020-02251-5

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